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Klinische Studien & Quellen

Hyperthermie:

https://oncotherm.de/klinische-publikationen

https://www.heckel-hyperthermia.com/index.php/de/de04

http://www.synchrotherm.com/index.php/en/clinical-studies

Cannabis & CBD:

CBD liefert therapeutische Verwendung für Erkrankungen wie Morbus Alzheimer, Morbus Parkinson, Krebs und Unfruchtbarkeit -Medizinische Fakultät, Universität von Louisville (USA)

httpss://www.ncbi.nlm.nih.gov/pubmed/29941868

THC und CBD dämmen das Wachstum von Burstkrebszellen ein

https://jpet.aspetjournals.org/content/early/2006/05/25/jpet.106.105247

Wirkungen von Cannabinoiden auf Nierenkrebs – Militärisches Institut für Medizin, Warschau (Polen)

httpss://www.ncbi.nlm.nih.gov/pubmed/29792186

Eindämmung der Ausbreitung von Blutkrebs durch Cannabinoide – Studie durch die Krebs Gesellschaft (Schweden)

https://molpharm.aspetjournals.org/content/70/5/1612

Krebsbekämpfende Wirkung bei Leukämie durch Aktivierung des CB1-Rezeptors Universität für medizinische Wissenschaften, Teheran, Iran

httpss://www.ncbi.nlm.nih.gov/pubmed/29883990

Fiebertherapie IL-2 & Langzeithyperthermie

O’Brien GC, Cahill RA, Bouchier-Hayes DJ, Redmond HP. Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma. Ir J Med Sci. 2006 Jan-Mar;175(1):10-4

Neary P et al: The evolving role of taurolidine in cancer therapy. Ann Surg Oncol. 2010 Apr;17(4):1135-43

Braumann C et al: Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial. World J Surg Oncol. 2009 Mar 23;7:32. doi: 10.1186/1477-7819-7-32

Marley K et al: The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro. BMC Vet Res. 2013 Jan 18;9:15. doi: 10.1186/1746-6148-9-15.

Stendel R et al: The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy. 2009 Feb;5(2):194-210. Epub 2009 Feb 13.

Jacobi CA et al: Taurolidine–a new drug with anti-tumor and anti-angiogenic effects. Anticancer Drugs. 2005 Oct;16(9):917-21.

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J. P. Allison, JAMA 1113 (2015).

M. A. Postow, M. K. Callahan, J. D. Wolchok, J Clin Oncol 33, 1974 (2015).

P. Attia et al., J Clin Oncol 23, 6043 (2005).

S. Slavin, R. W. Moss, T. Bakacs, Pharmacol. Res. (2013).

P. Boyle, Annals of Oncology 23, vi7 (2012).

A. Y. Michaels, A. R. Keraliya, S. H. Tirumani, A. B. Shinagare, N. H. Ramaiya, Insights. Imaging (2015).

V. G. de et al., Cancer Immunol Res 4, 12 (2016).

G. C. O’Brien, R. A. Cahill, D. J. Bouchier-Hayes, H. P. Redmond, Ir. J Med Sci 175, 10 (2006).

R. Kleef, W. B. Jonas, W. Knogler, W. Stenzinger, Neuroimmunomodulation 9, 55 (2001).

Skitzki JJ, Repasky EA, Evans SS (2009).

Curr Opin Investig Drugs. 10:550–558.Repasky EA, Evans SS, Dewhirst MW Cancer Immunol Res 1:210–216 (2013).

Möhler H., Pfirrmann R.W., Frei K. (Review), Int. J. of Oncology, 45, 1329- 1336 (2014).

PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. High-Dose Vitamin C (PDQ®): Health Professional Version. Bethesda (MD): National Cancer Institute (US); 2002-2016

O’Brien GC, Cahill RA, Bouchier-Hayes DJ, Redmond HP. Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma. Ir J Med Sci. 2006 Jan-Mar;175(1):10-4

Neary P et al: The evolving role of taurolidine in cancer therapy. Ann Surg Oncol. 2010 Apr;17(4):1135-43

Braumann C et al: Taurolidine reduces the tumor stimulating cytokine interleukin-1beta in patients with resectable gastrointestinal cancer: a multicentre prospective randomized trial. World J Surg Oncol. 2009 Mar 23;7:32. doi: 10.1186/1477-7819-7-32

Marley K et al: The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro. BMC Vet Res. 2013 Jan 18;9:15. doi: 10.1186/1746-6148-9-15.

Stendel R et al: The antibacterial substance taurolidine exhibits anti-neoplastic action based on a mixed type of programmed cell death. Autophagy. 2009 Feb;5(2):194-210. Epub 2009 Feb 13.

Jacobi CA et al: Taurolidine–a new drug with anti-tumor and anti-angiogenic effects. Anticancer Drugs. 2005 Oct;16(9):917-21.

O’Brien GC, Cahill RA, Bouchier-Hayes DJ, Redmond HP. Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma. Ir J Med Sci. 2006 Jan-Mar;175(1):10-4.

Kleef R et al. Near complete remission of pulmonary metastasis in triple negative breast cancer (TNBC) using low dose immune check point inhibitors (IC) with interleukin-2 (IL-2) and fever range hyperthermia. Abstract #166013, ASCO Annual meeting; Chicago, June 3-7, 2016 and 3rd Immunotherapy of Cancer

Zündorf I, Dingermann T.: Antikörper-Offensive gegen Krebs. DAZ 2015;27:46-50Conference; Munich: European Journal of Cancer S1-S30; 2016 p. S29-S30.

Integr Med (Encinitas). 2018 Dec; 17(6): 22–24. PMCID: PMC6469443 – PMID: 31043924 Ralf Kleef, MD: Unlocking the Power of the Immune System Against Cancer

Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2.

Kleef R, Moss R, Szasz AM, Bohdjalian A, Bojar H, Bakacs T. Integr Cancer Ther. 2018 Dec;17(4):1297-1303. doi: 10.1177/1534735418794867. Epub 2018 Sep 7. Erratum in: Integr Cancer Ther. 2019 Jan-Dec;18:1534735419854816.PMID:30193538

Durable Complete Response With Immune Checkpoint Inhibitor in Breast Cancer With High Tumor Mutational Burden and APOBEC Signature.Chumsri S, Sokol ES, Soyano-Muller AE, Parrondo RD, Reynolds GA, Nassar A, Thompson EA.J Natl Compr Canc Netw. 2020 May;18(5):517-521. doi: 10.6004/jnccn.2020.7543.PMID: 32380464

Compromise or not? A case report of successful treatment of pembrolizumab-induced hepatitis in a patient with non-small cell lung cancer with low-dose methylprednisolone and bicyclol.Liu Y, Zhang J, Yin Z, Zhu X, Xue L, Cao B.Thorac Cancer. 2020 May 7. doi: 10.1111/1759-7714.13463. [Epub ahead of print] PMID: 32379397

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