Complete Remission of Vocal Cord Cancer Treated With Low-Dose Ipilimumab Plus Nivolumab Combined With Interleukin-2 and Hyperthermia


You can read our latest publication here about a case of a 44-year-old male patient with a locally advanced, multiple recurrent squamous cell carcinoma of the vocal cord who had undergone resection several times. The patient rejected the mutilating surgery or radiation therapy and instead, he opted for complex immunotherapy combining low doses of checkpoint inhibitors with fever-inducing interleukin-2 and hyperthermia, which induced complete remission. Restaging with MRI and laryngoscopy demonstrated lasting remission ongoing now for two years. The fact that this patient is free of any cancer related signs or symptoms raises the possibility of a long-lasting remission even after the fourth recurrence of a locally advanced squamous cell vocal cord cancer by the induction of therapeutic fever combined with a safe low-dose ipilimumab plus nivolumab therapy to endorse T-cell function.





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